100 gram scale synthesis of a key intermediate of matrix metalloproteinase inhibitor in a continuous-flow system based on a copper-free sonogashira reaction using an ionic liquid as a catalyst support

摘要

The key intermediate of matrix metalloproteinase (MMP) inhibitor was synthesized using a flow microreactor for a copper-free Sonogashira coupling reaction in an ionic liquid. The ionic liquid [emim]NTfwas used as a solvent and a catalyst support. A 100 g scale synthesis was achieved in combination with a flow-extraction/catalyst-recycling system, in which the ionic liquid containing the palladium catalyst was continuously recycled.