Caspase inhibitor zVAD-fmk protects against acute pancreatitis-associated lung injury via inhibiting inflammation and apoptosis

Liu Mingdong; Shi Liangliang; Zou Xiaoping; Zheng Xi; Zhang Feng; Ding Xiwei; Zhu Hao; Shen Yonghua

首页> 外文期刊>Pancreatology: official journal of the International Association of Pancreatology (IAP) ... [et al.] >Caspase inhibitor zVAD-fmk protects against acute pancreatitis-associated lung injury via inhibiting inflammation and apoptosis

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Caspase inhibitor zVAD-fmk protects against acute pancreatitis-associated lung injury via inhibiting inflammation and apoptosis

机译：半胱天冬酶抑制剂zVAD-fmk通过抑制炎症和细胞凋亡来预防急性胰腺炎相关的肺损伤

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Background/objectives: Pulmonary apoptosis is an important pathogenic mechanism of acute lung injury induced by many factors. This study aims to investigate whether the caspase inhibitor zVAD-fmk has a protective effect against lung injury in the severe acute pancreatitis model (SAP) in rats.

机译：背景/目的：肺细胞凋亡是多种因素引起的急性肺损伤的重要发病机制。这项研究旨在探讨半胱天冬酶抑制剂zVAD-fmk在大鼠重症急性胰腺炎模型（SAP）中是否对肺损伤具有保护作用。

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来源
《Pancreatology: official journal of the International Association of Pancreatology (IAP) ... [et al.] 》 |2016年第5期| 共6页
作者
Liu Mingdong; Shi Liangliang; Zou Xiaoping; Zheng Xi; Zhang Feng; Ding Xiwei; Zhu Hao; Shen Yonghua;
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正文语种 eng
中图分类消化系及腹部疾病 ;
关键词
Caspase; zVAD-fmk; Acute pancreatitis-associated lung injury; Apoptosis; Inflammation;

机译：半胱天冬酶;zVAD-fmk;急性胰腺炎相关性肺损伤;细胞凋亡;炎症;

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1. Caspase inhibitor zVAD-fmk protects against acute pancreatitis-associated lung injury via inhibiting inflammation and apoptosis [J] . Liu Mingdong, Shi Liangliang, Zou Xiaoping, Pancreatology: official journal of the International Association of Pancreatology (IAP) ... [et al.] . 2016 ,第5期

机译：半胱天冬酶抑制剂zVAD-fmk通过抑制炎症和细胞凋亡来预防急性胰腺炎相关的肺损伤
2. Emodin Protects Against Acute Pancreatitis-Associated Lung Injury by Inhibiting NLPR3 Inflammasome Activation via Nrf2/HO-1 Signaling [J] . Zhenming Gao, Jidong Sui, Rong Fan, Drug Design, Development and Therapy . 2020 ,第1期

机译：通过NRF2 / HO-1信号传导抑制NLPR3炎性激活来保护急性胰腺炎相关肺损伤
3. Reduction of lung inflammation, oxidative stress and apoptosis by the PDE4 inhibitor roflumilast in experimental model of acute lung injury. [J] . P. Kosutova, P. Mikolka, M. Kolomaznik, Physiological Research . 2018 ,第Suppla4期

机译：在急性肺损伤的实验模型中，PDE4抑制剂罗氟司特可减轻肺部炎症，氧化应激和细胞凋亡。
4. 17-DMAG Inhibits Hemorrhage-induced Injury in Small Intestine and Lung by Inactivating Caspase-3 [C] . J.G. Kiang, S.C. Kiang, P.D. Bowman Conference on Shock . 2008

机译：17-DMAg通过灭活Caspase-3抑制出血诱导的小肠和肺部的损伤
5. Role of Covalent Modification of Hyaluronan with Inter-alpha Inhibitor Heavy Chains During Acute Lung Injury [D] . Ni, Kevin Chen. 2019

机译：急性肺损伤期间透明质酸与α间抑制剂重链共价修饰的作用。
6. Kallistatin protects against sepsis-related acute lung injury via inhibiting inflammation and apoptosis [O] . Wei-Chieh Lin, Chang-Wen Chen, Yu-Wen Huang, -1

机译：Kallistatin通过抑制炎症和细胞凋亡来预防败血症相关的急性肺损伤
7. Kallistatin protects against sepsis-related acute lung injury via inhibiting inflammation and apoptosis [O] . Wei-Chieh Lin, Chang-Wen Chen, Yu-Wen Huang, 2015

机译：Kallistatin通过抑制炎症和细胞凋亡来保护败血症相关的急性肺损伤

Caspase inhibitor zVAD-fmk protects against acute pancreatitis-associated lung injury via inhibiting inflammation and apoptosis

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