Rh-catalyzed sequential hydroarylation/hydrovinylation-heterocyclization of beta-(2-aminophenyl)-alpha,beta-ynones with organoboron derivatives: A new approach to functionalized quinolines

摘要

4-Aryl and 4-vinyl quinolines were prepared via a sequential procedure involving regioselective Rh(acae)(C2H2)/dppf-catalyzed hydroarylation/hydrovinylation of beta-(2-aminophenyl)-alpha,beta-ynones with arylboronic acids or potassium aryl and vinyl trifluoroborates, followed by nucleophilic attack of the amino group onto the carbonyl.