Novel approach towards the synthesis of 3,3a,4,5-tetrahydroquinolino-[4,3-c]isoxazole derivatives: Application to the preparation of previously unattainable 3a,4-dihydroazabenzopyrano[4,3-c]isoxazole scaffolds

摘要

A novel synthetic approach towards the preparation of 3-substituted-7,8-dimethoxy-3,3a,4,5-tetrahydroquinolino[4,3-c]isoxazole derivatives is reported. Further application of this methodology to the preparation of previously unattainable 3a,4-dihydroazabenzopyrano[4,3-c]isoxazole derivatives is also described.