Tetrabutylammonium Bromide Catalyzed Tandem Addition/Cyclization of o-Aralkynylaryl Aldehydes with Trimethyl(trifluoromethyl)silane: Synthesis of Trifluoromethyl Group Containing Phthalans

摘要

A tetrabutylammonium bromide catalyzed trifluoromethylation/ cyclization reaction of o-aralkynylaryl aldehydes with trimethyl(trifluoromethyl)silane and cesium fluoride has been developed. A variety of 1-alkylidene-3-(trifluoromethyl)phthalans were prepared in moderate to excellent yields by tandem nucleophilic addition and cyclization.