Versatile synthesis of amphiphilic oligo(Aliphatic-Glycerol) layer-block dendrons with different hydrophilic-lipophilic balance values

摘要

A series of amphiphilic oligo(glycerol-aliphatic) layer-blocked dendrons with different hydrophilic-lipophilic balance values (3.5-15.0) was prepared for use in controlled drug delivery and self-assembly studies. The synthetic strategies involved first a convergent growth of the inner hydrophobic sector followed by a divergent growth of the outer hydrophilic sector.