One-Pot Synthesis of Multiply Substituted Quinoline and Quinazoline Derivatives via [2+2+2] Cascade Annulation with Diaryliodonium Salts

摘要

An efficient and regioselective method to multisubstituted quinoline and quinazoline derivatives with diaryliodonium salts catalyzed by Cu(OTf)_2 has been presented. The reaction proceeded via cascade annulation in the mode of [2+2+2] form. This novel strategy enables use of readily available materials and bears great flexibility on the substitution groups.