A New Heterogeneous One-Pot Process for Both Nitroaldol (Henry) and Michael Reactions from Primary Haloalkanes via Nitroalkanes

摘要

At room temperature, one equivalent of primary haloalkane and aldehyde, or conjugated enone, in the presence of IRA-402 nitrite and Amberlyst A-21, gave β-nitroalkanols or γ-nitro ketones, respectively, via a one-pot tandem SN2-nitroaldol (Henry) or SN2-Michael reactions.