Regioselective hydrochalcogenation reaction of 1,2-allenyl phosphine oxides: A novel synthesis of beta-organochalcogenyl allyl phosphine oxides

摘要

Organyl thiolate, selenolate or tellurolate anions reacted with allenyl phosphine oxides to give beta-(organochalcogenyl)allyl phosphine oxides in good yields. The reaction was regioselective, giving exclusively one isomer in all cases studied. The palladium-catalyzed cross-coupling of compound 3d with terminal alkynes to give beta-alkynyl allyl phosphine oxide underwent efficiently in moderate yields.