Phosphomolybdic acid supported on silica gel: An efficient, mild and reusable catalyst for the chemoselective hydrolysis of acetonides

摘要

Carbohydrate acetonides were chemoselectively cleaved to the corresponding diols by Using environmentally benign phosphomolybdic acid (H3PMo12O40) supported on silica gel (PMA-SiO2) at ambient temperature in a short span of 5-7 Minutes in acetonitrile. Acid-labile protective groups such as THP, TBS, TBDPS, MOM, OMe and PMB were found to be stable under the reaction conditions.