Organocatalytic Asymmetric Triple Domino Reactions of Nitromethane withα,β-Unsaturated Aldehydes

摘要

An organocatalytic asymmetric multicomponent dominoreaction employing the bulk chemical nitromethane and a,13-unsat-urated aldehydes as substrates is described. The new triple cascadereaction based on two subsequent Michael additions and an in-tramolecular aldol condensation provides an atom-economic entryto diastereo- and enantiomerically pure 5-nitrocyclohexene carbal-dehydes after flash chromatography.