A practical and user-friendly method for the selenium-free one-step preparation of 1,2-diketones and their monoxime analogs

摘要

Treatment of alpha-methylene ketones with excess sodium nitrite and aqueous HCl in THF at reduced temperatures provides an effective tool for the preparation of a variety of 1,2-diketones. The diastereoselective synthesis of the corresponding (Z)-1,2-dione monoximes could be accomplished under similar conditions, but by using only one equivalent of nitrosating reagent.