Rapid assembly of the 1-azabicyclo[3.1.0]hexane skeleton of ficellomycin

摘要

The 1-azabicyclo[3.1.0]hexane core of ficellomycin can be assembled in a concise manner by way of a double cyclisation reaction involving in situ generation of an NH aziridine and further intramolecular conjugate addition onto a dehydroamino ester.