Stereoselective synthesis of new enantiopure building blocks for the preparation of steroids

摘要

The enantiopure alpha,beta-unsaturated ketone 4 was synthesised from indanone 2 by a palladium-catalysed hydrogenolysis of allylic formate 10 followed by deprotection of TBS-ether 11 and oxidation with MnO2. [References: 43]