A New Class of Squaramide-Containing Phase-Transfer Catalysts: Application to Asymmetric Fluorination of beta-Keto Esters

摘要

The squaramide moiety has proven to be a powerful hydrogen-bonding donor in organocatalysis, but chiral phase-transfer catalysts bearing the squaramide motif have not been reported so far. Reported herein is this kind of catalyst and their catalytic performance in the asymmetric fluorination of beta-keto esters.