A Facile Synthetic Route for the Preparation of 4-Substituted 6-Methyl-2-pyrone Derivatives via Organozinc Reagents

摘要

A novel synthetic pathway for the preparation of 4-sub-stituted 2-pyrone derivatives has been developed. It consists of two different methods; the first represents the Negishi coupling reaction utilizing easily accessible organozinc reagents. More significantly, the other is a new method utilizing a new organozinc reagent, 4-py-ronylzinc bromide, which is easily prepared by highly active zinc under mild conditions.