A simple and very efficient route to new chiral ferrocenyl diamines via diastereoselective alkylation

摘要

A new family of chiral ferrocenyl diamines bearing one planar chirality and one or two stereogenic centers has been easily synthesised starting from 2-(N,N-dimethylaminomethyl)ferrocenylcarboxaldehyde (1) via a highly diastereoselective step. All diamines were obtained in high diastereomeric excesses and optical purities (de and ee > 98%) and in 80% to 85% yields. [References: 17]