Palladium(II)-Catalyzed Auxiliary-Directed C–H Activation for the Regio-selective ortho Arylation of N-(2-Benzoylphenyl)benzamides

摘要

A highly regioselective ortho arylation of N-(2-ben-zoylphenyl)benzamides has been achieved with aryl iodides in the presence of 10 mol% Pd(OAc)_2 and a stoichiometric amount of AgOAc under solvent-free conditions via C—H activation to pro-duce the corresponding 2-arylated benzamides in good yields.