Enantioenriched isoindolinones from chiral phase-transfer-catalyzed intramolecular aza-michael reactions

摘要

Optically active isoindolinones are synthesized by asymmetric intramolecular aza-Michael reactions using cinchoninium phase-transfer organocatalysts. The resulting compounds are useful intermediates for the synthesis and development of benzodiazepine-receptor agonists.