Reversal of asymmetric induction in arenetricarbonyl-chromium(0) complexes via dilithiation with the (-)-sparteine/BuLi system and enantioselective quench

摘要

Dilithiation of methoxymethoxyarenetricarbonylchromium complexes by 2.5 equivalents of BuLi and 6 equivalents of (-)-sparteine followed by enantioselective electrophilic quench gave the planar chiral (R)-enantiomers in up to 95% enantiomeric excess. This was the opposite enantiomer obtained under conditions for enantioselective monolithiation with (-)-sparteine/BuLi. [References: 14]