Optically active chiral ligands, ferrocenyloxazolinylphosphines (FOXAPs): Development and application to catalytic asymmetric reactions

摘要

The development of optically active chiral ligands, ferrocenyloxazolinylphosphines (FOXAPS), and their application to catalytic asymmetric reactions are reviewed. FOXAPs have been prepared in high yields from the corresponding chiral oxazolinylferrocenes via diastereoselective lithiation followed by quenching with chlorodiphenylpbosphine. They work quite effectively as chiral ligands for a variety of transition-metal-catalyzed asymmetric reactions such as hydrosilylation and transfer hydrogenation of ketones and imines, kinetic resolution of alcohols, carbon-carbon bond-forming reactions and ring-opening reactions.