Synthesis of the C9-C21 Fragment of Geldanamycin via a Diastereoselective Substrate-Controlled Hydrogenation

摘要

An Ir-catalyzed diastereoselective hydrogenation was employed to establish the stereogenic center at carbon atom C 14 of a C9-C21 fragment of geldanamycin. The fragment was stereoselectively synthesized from D-mannitol in 18 steps.