New Approach to a Novel Axially Chiral Ligand Showing Spontaneous Enrichment of Axial Chirality

摘要

We have synthesized novel axially chiral with two chiral centers, (R)-(R)_2- and (S)-(S)_2-2,2'-bis(2,2,2-trifluoro-1-hydroxyethyl)biphenyl (1), which showed a high asymmetric induction when used as ligand. Here, another new approach to 1 by kinetic and thermodynamic resolution is presented which gave these ligands in a much shorter steps, in a higher yield, and in a higher enantiomeric excess.