Lack of antibodies to neuropil antigens in idiopathic REM sleep behavior disorder

摘要

Autoimmune encephalitides associated with antibodies to neu-ronal cell surface or synaptic proteins represent an expanding group of potentially treatable disorders [1 ], which can manifest with disrupted sleep patterns including REM sleep behavior disorder (RBD) [1,2]. As female patients with early-onset (before age 50) RBD, especially those with the idiopathic form (iRBD), are comorbid for various autoimmune diseases [3], a role for autoimmunity in RBD/ iRBD pathogenesis can be hypothesized. Anti-locus coeruleus antibodies in sera of 10 RBD patients were absent in the only study on the topic [41.