Oxazaborolidione-Catalyzed Asymmetric Mukaiyama Aldol Reaction of Ketones

摘要

The Harada group has developed OXBderived from allo-threonine and reported that OXBis an efficient catalyst for various asymmetric reac-tions (J. Org. Chem. 2008, 73, 212). In this paper,they extended the application of this catalyst to the Mukaiyama aldol reaction of nonactivated ke-tones. They proposed an activated complex asshown above to rationalize the absolute stereo-chemistry of the reaction.