Mild cognitive impairment in rapid eye movement sleep behavior disorder: A predictor of dementia?

摘要

Due to the growing evidence of the association between idio-pathic rapid eye movement sleep behavior disorder (iRBD) and the synucleinopathy neurodegenerative disorders, including Parkinson disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA), iRBD is increasingly considered as a prodromal phase of these disorders prior to the development of overt neurologic deficits [1-4]. Due to the high conversion rate of iRBD to PD, DLB, or MSA, reaching up to 82% of iRBD patients with longitudinal follow-up in recent reports, there is keen interest in elucidating biomarkers and predictors for future neurodegenera-tion, which would afford opportunities for implementing clinical trials of candidate neuroprotective therapies [l-4].