Protein-protein Interactions as Target for New Therapeutic Molecules

摘要

Major human diseases are caused or are associated with disturbances of compartmentalised cyclic adenosine monophosphate (cAMP) signalling networks.The participants of the European research project "thera-cAMP" aim to identify lead compounds,which specifically modulate protein-protein interactions in such signalling cascades.The approach could lead to alternative strategies for the treatment for diseases that are currently not addressed effectively by conventional pharmacotherapy.