Effects of obstructive sleep apnea severity on serum lipid levels in Greek children with snoring.

摘要

BACKGROUND: Although obstructive sleep apnea (OSA) is related to dyslipidemia in adults, limited data are available regarding its effects on serum lipids during childhood. Aim of this study was to assess the potential relationships between severity of OSA and cholesterol or triglyceride levels in a cohort of Greek children. METHODS: Data from children with snoring who underwent polysomnography and complete serum lipids measurements during a specified study period were analyzed retrospectively. RESULTS: Overall, obese children (n = 261) had lower HDL cholesterol levels than non-obese subjects (n = 113) (49.6 +/- 10.5 vs. 53.9 +/- 11.4 mg/dL; p = 0.001) and higher triglyceride concentrations (69.8 +/- 32.2 vs. 63.2 +/- 27 mg/dL; p = 0.041). Non-obese subjects with moderate-to-severe OSA did not differ in triglycerides, total, and LDL cholesterol concentrations but had lower HDL cholesterol, when compared to non-obese children with primary snoring/mild OSA (50.4 +/- 13.1 vs. 54.9 +/- 10.7 mg/dL; p = 0.008). The risk for having low HDL cholesterol (