Measuring nuclear factor-KB--who cares?

摘要

A convincing body of evidence now exists that obstructive sleep apnea syndrome (OSAS) is associated with cardiovascular morbidity and mortality [1-3]. OSAS has been specifically associated with hypertension , myo-cardial infarctions , stroke , and congestive heart failure . Apneic episodes and arousals cause surges in sympathetic tone with the release of vasoactive mediators including cate-cholamines . Intermittent hypoxia leads to hypoxic vasoconstriction and hypoxia reperfusion oxidative stresses . These metabolic stresses result in a systemic inflammatory response and vascular remodeling.