A Straightforward Method for the Synthesis of Alkylidene and Arylidene Malonates Through Proline-Catalyzed Knoevenagel Condensation

Giuliana Cardillo; Serena Fabbroni; Luca Gentilucci; Massimo Gianotti; Alessandra Tolomelli

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A Straightforward Method for the Synthesis of Alkylidene and Arylidene Malonates Through Proline-Catalyzed Knoevenagel Condensation

机译：脯氨酸催化的Knoevenagel缩合反应合成亚烷基和丙二酸丙二酸酯的简单方法

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摘要

Astraightforward method for the synthesis of alkylidene/arylidene maloates and arylidene cyanoacetates,utilizing proline as an alternative to traditional catalysts is presented.Alarge numbdr of unsaturated esters was obtained from the Knoeveagel reaction under very mild conditions and utilizing cheap reagents.

机译：提出了一种脯氨酸替代传统催化剂的简单方法，用于合成亚烷基/亚芳基苹果酸和亚芳基氰基乙酸酯。在非常温和的条件下，使用廉价的试剂，通过Knoeveagel反应可得到大量的不饱和酯。

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《Synthetic Communications 》 |2003年第9期| 共8页
作者
Giuliana Cardillo; Serena Fabbroni; Luca Gentilucci; Massimo Gianotti; Alessandra Tolomelli;
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正文语种 eng
中图分类有机化学 ;
关键词
Knoevengel condensation; Proline; Alkylidene malo-nate; Arylidene malonate; Arylidene cyanoacetate.;

机译：Knoevengel缩合;脯氨酸;苹果酸亚烷基酯;丙二酸亚芳基酯;氰基乙酸亚芳基酯。;

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1. A Straightforward Method for the Synthesis of Alkylidene and Arylidene Malonates Through Proline-Catalyzed Knoevenagel Condensation [J] . Giuliana Cardillo, Serena Fabbroni, Luca Gentilucci, Synthetic Communications . 2003 ,第9期

机译：脯氨酸催化的Knoevenagel缩合反应合成亚烷基和丙二酸丙二酸酯的简单方法
2. Tandem knoevenagel - Michael addition of aryl sulfonimines with diethyl malonate for synthesis of arylidene dimalonates [J] . Fan R, Wang W, Pu D, The Journal of Organic Chemistry . 2007 ,第15期

机译：串联knoevenagel-芳基亚磺胺与丙二酸二乙酯的迈克尔加成反应合成亚芳基二丙二酸酯
3. Tandem Knoevenagel—Michael Addition of Aryl Sulfonimines with Diethyl Malonate for Synthesis of Arylidene Dimalonates [J] . Renhua Fan, Weizi Wang, Dongming Pu, The Journal of Organic Chemistry . 2007 ,第15期

机译：串联Knoevenagel-芳基亚磺胺与丙二酸二乙酯的迈克尔加成反应合成亚芳基二烯丙酸酯
4. An Useful Synthesis of Polyhydroxyalkyl-Heterocycles by Knoevenagel Condensation of Aldoses with Dicarbonyl Compounds(Abstracts) [C] . Giustino Di Antonio, Giuseppe Bartoli, Riccardo Giovannini European Symposium on Organic Chemistry . 2007

机译：用二羰基化合物的醛固醇缩合的多羟基烷基杂环的有用合成（摘要）
5. 1. Studies directed toward the synthesis of 20B-carbachaparrinone analogs via a samarium (II) iodide ring closure of a highly functionalized intermediate. 2. Synthesis of 5-oxo-cyclopent-1-enecarboxylic acid methyl esters via a novel tandem aldol-knoevenagel condensation. 3. Novel carbocyclic ring formation via intramolecular enol trapping of an allyl cation in acidic polar media. [D] . DeSelms, Robert Herschel. 2002

机译：1.研究针对通过高度官能化中间体的碘化sa（II）闭环合成20B-氨基苯甲酰吗啉酮类似物。 2.通过新型串联的羟醛-knoevenagel缩合合成5-氧代-环戊-1-烯羧酸甲酯。 3.通过在酸性极性介质中烯丙基阳离子的分子内烯醇捕获而形成新的碳环。
6. Selection synthesis and anti-inflammatory evaluation of the arylidene malonate derivatives as TLR4 signaling inhibitors [O] . Shuting Zhang, Kui Cheng, Xiaohui Wang, -1

机译：亚氨基丙二醇酯衍生物作为TLR4信号抑制剂的选择合成和抗炎评价
7. Tandem Knoevenagel-Michael Addition of Aryl Sulfonimines with Diethyl Malonate for Synthesis of Arylidene Dimalonates [O] . -1

机译：串联Knoevenagel-Michael加入芳基磺酰亚胺与丙二酸二乙酯合成亚亚基二醛酸盐

A Straightforward Method for the Synthesis of Alkylidene and Arylidene Malonates Through Proline-Catalyzed Knoevenagel Condensation

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