Synthesis of Highly Functionalized Arene Systems. Novel Selectivities of Intra-and Intermolecular Friedel-Crafts Reactions

摘要

The intermolecular Friedel-Crafts acylation of electron-rich aromatic rings can be difficult in the presence of easily ionized groups. During these studies directed toward the synthesis of colchicine, it was observed that the stability of the cation is key to controlling alternative competing processes.