A Novel Base-Promoted Rearrangement Of Eudesmanolide Sesquiterpenoid To The Salvialane Sesquiterpene

摘要

An eudesmanolide sesquiterpene epoxide has been transformed to an #alpha#-hydroxy ketone with the salviane sesquiterpene skeleton through a novel carbon-carbon rearrangement promoted by excess of NaOMe in Et_2O at room temperture which accomplished the first synthesis of the salviane kind os sesquiterpene skeleton. A possible reaction mechanism is also discussed