Simple, one-pot, and three-component coupling reactions of azaarenes (phenanthridine, isoquinoline, and quinoline), with acetylenic esters involving methyl propiolate or ethyl propiolate in the presence of NH-heterocyclic or 1,3-dicarbonyl compounds

摘要

Three-component reactions involving azaarenes (quinoline, isoquinoline, and phenanthridine) with acetylenic esters such as methyl propiolate or ethyl propiolate in the presence of NH-heterocyclic compounds (carbazole, maleimide, 5-nitroindazole, 2-benzoxazolinone, indole, and 2-methylindole) or 1,3-dicarbonyl compounds involving acetylacetone and N,N-dimethylbar bituric acid are described. The reactions proceeded smoothly at room temperature without a catalyst and with excellent yields. This method is very useful for functionalizing aza-aromatic compounds in a one-pot operation.