SYNTHESIS OF 1,4-DIHYDROPYRIDINES BY REGIOSELECTIVE ADDITIONS OF BENZYLIC ZINC BROMIDES TO PYRIDINIUM SALTS AND THEIR AROMATIZATIONS TO 4-BENZYLPYRIDINES

摘要

Benzylic zinc reagents add with high regioselectivity to 1-(phenoxycarbonyl) salts of methyl nicotinate to yield methyl-1-(phenoxylcarbonyl)-4-benzyl-1,4-dihydronicotinates. The dihydronicotinates on heating with sulfur in decalin afford methyl 4-benzyinicotinates. [References: 36]