Efficient one-pot Friedel-Crafts acylation of benzene and its derivatives with unprotected aminocarboxylic acids in polyphosphoric acid

摘要

A number of aminobenzophenones have been synthesized by acylation of benzene and its derivatives with different 2-, 3-, 4-aminobenzoic and 4-aminophenylacetic acids in polyphosphoric acid via Friedel - Crafts reaction as compounds with expected antitumor activity.