Microwave-Assisted Beckmann Rearrangement:Convenient Synthesis of l,3-Diaza-bicyclo[3.2.2]nonane

摘要

Small heterocyclic amines such as 1,3-diaza-bicyclo[3.2.2]nonane are known to be key components of biologically active molecules.A convenient synthesis of this compound utilizing a key Beckmann rearrangement of (Z)-1 -aza-bicy-clo[2.2.2]octan-3-one oxime (6)with cone.H_2SO_4 under microwave irradiation was achieved.The desired compound (1)was obtained in 20% yield overall.