Novel carbon-carbon bond formation between N-methyl-3-phenyl-3-hydroxypropylamine and cresols catalyzed by p-toluenesulphonic acid

摘要

The p-toluenesulphonic acid-catalyzed reaction between appropriate cresols and N-methyl-3-phenyl-3-hydroxypropylamine in refluxing toluene resulted in the formation of o-substituted phenol derivatives by an aromatic nucleophilic substitution reaction.