Comment on: Surgical adhesive increases burst pressure and seals leaks in stapled gastrojejunostomy.

摘要

This laboratory study showed that the application of Bio-Glue resulted in a rather remarkable improvement in the acute bursting pressure in fresh stapled porcine gastrojejunostomies. The investigators' method documented the anastomotic integrity by demonstrating no leak in the submerged specimens at the lowest measured ah" pressure. Anastomotic healing did not occur, because the specimens were explanted within minutes of performing the anastomosis. In the leak model, BioGlue again provided a significant increase in bursting strength that appeared to be substantially, if not significantly, greater than that of the intact control anastomoses in experiment 1. It is not entirely clear whether the 10 anastomoses in experiment 2 served as their own controls, which would seem legitimate, as well as economical.These experiments are similar to those using other sealants to reinforce either the staple lines or the anastomoses in the bowel. The authors acknowledge that their experiments did not address anastomotic healing "over time."