18FDG PET-CT for detecting gastric cancer recurrence after surgical resection: A meta-analysis

摘要

Background: We performed a meta-analysis to evaluate the value of 18FDG PET-CT for the detection of gastric cancer recurrence after surgical resection. Methods: A systematic literature search was performed in the MEDLINE and EMBASE databases. We calculated the sensitivity, specificity, positive likelihood ratio, and negative likelihood ratio for 18FDG PET-CT. We also constructed summary receiver operating characteristic curves for 18FDG PET-CT. Results: Eight studies (500 patients) were included. The sensitivity, specificity, positive likelihood ratio and negative likelihood ratio of 18FDG PET-CT were 0.86 (95% confidence interval [CI] = 0.71-0.94), 0.88 (95% CI = 0.75-0.94), 17.0 (95% CI = 3.5-14.0), and 0.16 (95% CI = 0.07-0.34), respectively. Overall weighted area under the curve was 0.93 (95% CI = 0.91-0.95). Conclusions: 18FDG PET-CT has moderate sensitivity and specificity for detection of gastric cancer recurrence after surgical resection. Crown