Development of new spectrophotometric method for the determination of Rupatadine fumarate in bulk and its formulations using acid potassium permanganate and fast green FCF dye

摘要

Simple, sensitive and selective visible spectrophotometric method for the determination of Rupatadine fumarate (RPF) in bulk and formulations through oxidation reaction of the olefenic double bond is proposed. The Method is based on the reaction of potassium permanganate to the olefenic double bond in RPF and estimating the unreacted permanganate with fast green FCF (FGFCF). The color produced in method has maximum absorption at 620nm. Beer's law obeyed in the concentration range of 16-80μg/ml. Its molar absorptivity is 5.9577x10~4. The precision and accuracy of the method is checked by the reported UV reference method in 0. IN HC1 at λ_(max) 252nm. No interference was observed from the usually existing additives in pharmaceutical formulations and the applicability of the method was examined by analyzing commercial available tablets containing RPF. The method is found to be suitable for the determination of Rupatadine fumarate.