Altered Astrocyte-Neuronal Interactions After Hypoxia-Ischemia in the Neonatal Brain in Female and Male Rats

摘要

Background and Purpose-Increased susceptibility to excitotoxicity of the neonatal brain after hypoxia-ischemia (HI) may be caused by limited capacity of astrocytes for glutamate uptake, and mitochondrial failure probably plays a key role in the delayed injury cascade. Male infants have poorer outcome than females after HI, possibly linked to differential intermediary metabolism.