H-1 and C-13 NMR determination of the enantiomeric purity of substituted 4-amino-3-(thien-2-yl)-butyric acids and 4-amino-3-(benzo[b]furan-2-yl)-butyric acids, ligands of the GABA(B) receptor.

摘要

The enantiomeric composition and absolute configuration of 4-Amino-3-(benzo[b]furan-2-yl)- Butanoic Acids and of 4-Amino-3-(thien-2-yl)- Butanoic Acids 1 may be accurately determined by H-1 and C-13 nuclear magnetic resonance analysis of the corresponding derivatives 3 prepared by reaction with chiral reagents. Correlation with HPLC is signaled. [References: 26]