Synthesis and structural and biological activity studies on some lanthanide chelates with O- and N-containing ligands

摘要

The synthesis of Ce3+, Th4+, and UO22+ complexes with six azo compounds based on 4-methyl-6,7-dihydroxy-8-arylazo coumarin is reported. The azo compounds were expected to coordinate through O and N either in the azo or in the hydrazone form, but different physicochemical studies (elemental and thermal analysis, molar conductance, IR, magnetic susceptibility, H-1-NMR, and electronic absorption spectra) show that they coordinate via O, O with the coumarins acting as mono (or sometimes di-) basic and bidentate ligands. Biological activity of some complexes has been evaluated against some filamentous microscopic fungi, yeast, and bacteria. The results are compared to those of the free ligands.