Determination of certain antispasmodic drugs as single ingredient, mebeverine hydrochloride, and in two component mixtures, mebeverine hydrochloride-sulpiride and isopropamide iodide-trifluoperazine hydrochloride

摘要

Two simple and sensitive methods are described for the quantitative determination of mebeverine hydrochloride as single ingredient. The first method depends on the application of quantitative H-1-NMR spectroscopy using deuterated chloroform and hexamine as an internal reference standard. The second method is based on measuring the native fluorescence of mebeverine hydrochloride in 0.1 N sulphuric acid at 360 nm with excitation at 290 nm. Furthermore simultaneous determinations of two component mixtures, mebeverine hydrochloride with sulpiride and isopropamide iodide with trifluoperazine hydrochloride are presented using first-derivative and second-derivative UV-spectrophotometry, respectively. The proposed methods have been successfully applied to the determination of the cited drugs in commercial tablets. Compared with the reference methods, the proposed methods are more sensitive, with good accuracy and reproducibility. [References: 15]