The functional units in cells are often assemblies of macromolecules, including proteins and nucleic acids. Therefore, the knowledge of structure, dynamics, and energetics of macromolecular complexes is necessary for a mechanistic description of biochemical and cellular processes. This special issue of Structure, "Macromolecular Assemblies Highlighted," presents ten research articles and five reviews on the determination, representation, visualization, archival, and dissemination of assembly structure and dynamics.
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