Facile solid state ball milling as a green strategy to prepare 2-(2,4-dichlorophenoxy)-N'-(2-hydroxybenzylidene)acetohydrazide complexes

摘要

2-(2,4-Dichlorophenoxy)-N'-(2-hydroxybenzylidene)acetohydrazide (H_2L) complexes were prepared by ball milling involving the reaction of ligand with Ni(II), Co(II), Cu(II) and VO(II) salts (mechanochemical syntheses). The compounds were elucidated by elemental analysis, spectroscopy (~1H NMR, IR, UV–visible, MS spectra), and physical measurements (magnetic susceptibility and molar conductance). IR spectra suggested that the H_2L behaved as a monodentate and/or bidentate ligand coordinating via azomethine nitrogen and/or deprotonated enolized carbonyl oxygen. The electronic spectra of the complexes and their magnetic moments provided information about geometries. The antimicrobial activities of the ligand and its complexes were studied against gram positive bacteria; Staphylococcus aureus, gramnegative bacteria; Escherichia coli and pathogenic fungi; Candida albicans by using minimum inhibition concentrations method (MIC). Also, the antioxidant (ABTS-derived free radical method) and cytotoxic (in vitro Ehrlich Ascites) activities of the isolated compounds were evaluated.