Synthesis, characterization and bioactive evaluation of copper(II) 5, 10, 15,20tetrakis[α,α,α,α-2-(2,6-bis(4-methylpiperazine-l- yl-methyl)-4-iminomethyl phenol)phenyl] porphyrin: A picket-fence porphyrin

摘要

We are interested in constructing deeper small cavities by adding more bulky substituents at the ortho-phenyl positions of tetrakis(o-aminophenyl) porphyrin. The synthesis of picket-fence porphyrin is initiated by the preparation of the tetrakis(o-nitrophenyl)porphyrin followed by the nitro to amino reduction and subsequent condensation with Schiff base ligand to form imine linkages of porphyrin complexes. The synthesis and characterization of a new series of picket-fence porphyrins and their copper complexes are described. 5,10,15,20-Tetrakis[α,α,o-2-(2,6-bis(4-methyl piperazine-l-yl- methyl)-4-iminomethyl phenol)phenyl] porphyrin can be synthesized from 2,6bis[4-methylpiperazin-l-yl-methyl]-4-formylphenol (L) and 5,10,15,20-tetra[α,α,α,α-o-nitrophenyl]porphyrin. 5,10,15,20-Tetra[α,α-porphyrin was obtained by the reduction of 5,10,15,20-tetra[α,α,α,α-o-nitrophenyl -porphyrin. The spectral, electrochemical, antibacterial, antifungal and cytotoxicity properties of all the picket-fence porphyrin complexes were characterized and studied.