The trigeminovascular system does not require a peripheral sensory input to be activated-migraine is a central disorder: Focus on 'Effect of cortical spreading depression on basal and evoked traffic in the trigeminovascular sensory system'

摘要

Similarities between Leao's cortical spreading depression (CSD) , the propagation rate of Lashley's sco-toma , and perfusion changes occurring during migraine aura have led to the hypothesis that CSD is the animal equivalent and the probable mechanism that underlies migraine aura . These data helped change thinking from vascular theories postulated by Wolff to a more neuronal basis of migraine. Perhaps as a consequence, the importance or role of migraine aura (or CSD) in migraine pathophysiology has been overstated so that it is sometimes considered essential even in patients without clinically manifest aura.