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摘要

The field of cartilage repair continues to advance after the advent of cell-based and single-stage chondrocyte implantation technologies. Cartilage restoration through first-generation techniques such as marrow stimulation, osteochondral autografting and allografting, and autologous chondrocyte implantation has a proven track record. However, newer second-generation and third-generation cell-based technologies are being developed and tested clinically with the purposes of decreasing operative morbidity, the ability to use a single-stage approach, and improve the viability and durability of cartilage repair tissue.This issue of Sports Medicine and Arthroscopy Review is dedicated to providing an overview of both the current and emerging cartilage restoration technologies. The contributors are pioneers in the field of cartilage regeneration and have covered topics such as the Food and Drug Administration regulatory pathway for biologics,cell-based and single-stage cartilage transplantation, advanced imaging of cartilage repair, and fourth-generation emerging technologies. The authors have provided a comprehensive review of the latest in cartilage restoration technology, and have highlighted not only the science behind the development of cell-based technologies but also emerging surgical techniques for cartilage repair.
机译:在基于细胞的单阶段软骨细胞植入技术问世后,软骨修复领域继续发展。通过第一代技术(例如骨髓刺激,骨软骨自体移植和同种异体移植以及自体软骨细胞植入)进行的软骨修复已被证明是成功的记录。但是,目前正在研发新的基于第二代和第三代细胞的技术,并在临床上对其进行测试,目的是降低手术发病率,采用单阶段方法的能力以及提高软骨修复组织的生存力和耐用性。 《运动医学与关节镜检查》(Sports Medicine and Arthroscopy Review)一期致力于概述当前和新兴的软骨修复技术。贡献者是软骨再生领域的先驱,涵盖了诸如食品和药物管理局针对生物制剂的监管途径,基于细胞的单阶段软骨移植,软骨修复的高级成像以及第四代新兴技术等主题。作者对最新的软骨修复技术进行了全面的综述,不仅强调了基于细胞的技术发展背后的科学,而且强调了新兴的软骨修复外科技术。

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