METHOD FOR TESTING A SUBSTANCE WHICH IS POTENTIALLY ACTIVE IN THE FIELD OF LIPOLYSIS AND ITS MAINLY COSMETIC USE

摘要

Assignee BASF Beauty Care Solutions The patent describes a method of testing a substance potentially active in the field of lipolysis. It comprises preparing a substrate containing at least one triacylglycerol; placing this substrate in contact with a substance potentially active in the field of lipolysis and with a lipoprotein lipase, in the presence of a cofactor of lipoprotein lipase. The mixture is left for a period of time sufficient to release at least in part one fatty acid of the triacylglycerol. The capacity to inhibit the release of the fatty acid resulting from the activity of the lipoprotein lipase, under the action of the potentially active substance is evaluated. Results are compared with the result obtained in the absence of the potentially active substance or compared with the result obtained in the presence of a known inhibitor acting as reference.